FMT & Gut Therapeutics

Faecal microbiota transplant has moved from fringe curiosity to one of the most studied therapies in gastroenterology. What the evidence actually says in 2026: cure rates above 90 per cent in recurrent C. difficile, antibiotic-FMT combination protocols for ulcerative colitis, a modest but real signal in IBS, and a rapidly expanding frontier in depression, bipolar disorder, and autism — alongside the multi-modal, multi-donor Shore protocol that reflects where the science has l

Can a faecal microbiota transplant stabilise a mood disorder that has resisted every combination of psychiatric medication? The early evidence — and a growing body of compelling case reports — suggests that in carefully selected patients, the answer may be yes. For patients with severe treatment-resistant bipolar depression, FMT is no longer a theoretical curiosity. Delivered in the right clinical framework, it can meaningfully reduce antidepressant burden and restore mood st

When you take an antibiotic tablet for a gut infection, you might reasonably assume that the medication goes directly to where the infection is. The reality is very different. Oral antibiotics are absorbed through the stomach and small intestine into the bloodstream. They are distributed throughout the entire body, metabolised by the liver, and only a fraction of the original dose ultimately reaches the colon — where the parasites actually live. This pharmacokinetic reality e

What if the most effective treatment for your chronic gut condition was not a pill, not a supplement, and not another restrictive diet — but a transplant of healthy gut bacteria from a carefully screened donor? That is the premise behind Faecal Microbiota Transplantation, or FMT, and it is one of the most exciting frontiers in modern gastroenterology. FMT is not a fringe therapy. It is backed by robust clinical evidence, endorsed by international gastroenterology societies fo